is enhanced rapidly and then lost slowly. Since this sequence of events could be an important control mech- anism in blood coagulation, we have attempted to char- acterize further the reactions of purified human FwI/ vWF' with thrombin. The extent of thrombin-induced activation of FVIII/vWF was found to be dependent on the ratio of thrombin to FVIII/vWF. The extent of activation continued to increase with increasing throm- bin to
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Switzer et al. (1980) studied this question.
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