Answers are grounded in this paper and cite their sources.
relevance of these results, circulating ET-1, muscular strength, muscular fibrosis and p16 expression were measured in male C57Bl6 mice from 5-18-24-months-old. Old mice shown high levels of ET-1 correlated with muscular fibrosis, muscular p16 expression and loss of muscle strength. In conclusion, ET-1 promotes fibrosis and senescence in cultured myoblasts, similar results were found in old mice, suggesting a potential role for ET-1 in the development of sarcopenia related to aging.
No takes yet. Share an insight, caveat, or question.
Alcalde‐Estévez et al. (2020) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: