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Basophils are believed to play an important role in the pathophysiology of chronic idiopathic/spontaneous urticaria (CIU/CSU) (Vonakis and Saini, 2008). Notably, basopenia has been reported in patients with CIU/CSU (Rorsman, 1961) and is postulated to be the result of migration of basophils from the circulation into the skin (Caproni et al., 2005; Ito et al., 2011; Ying et al., 2002). Consistent with this hypothesis, the degree of basopenia has been shown to correlate with disease severity (Grattan et al., 2003) and improves during times of remission (Eckman et al., 2008; Kern and Lichtenstein, 1976).
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Saini et al. (2016) studied this question.
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