Why the study?
A novel size-adjustable cryoballoon can deliver therapy at 28- or 31-mm sizes, but data on antral lesion size with the 31-mm balloon size are scarce.
Does cryoablation with a 31-mm size-adjustable cryoballoon produce adequate antral lesions in patients with paroxysmal atrial fibrillation undergoing first-time PVI?
Does cryoablation with a 31-mm size-adjustable cryoballoon produce adequate antral lesions in patients with paroxysmal atrial fibrillation undergoing first-time PVI?
The 31-mm size-adjustable cryoballoon creates large antral lesions and achieves complete PVI, though it may leave proarrhythmogenic nonablated corridors on the roof in small atria.
Provides initial antral lesion data with 31-mm cryoballoon; leaves open impact on PVI durability or outcomes.
Background A novel size-adjustable cryoballoon can deliver cryotherapy with a 28- or 31-mm balloon size. However, data on antral lesion size with the 31-mm balloon size are scarce. Objective The purpose of this study was to evaluate the antral lesion size of cryoablation with the 31-mm balloon size. Methods This prospective single-center study included patients with paroxysmal atrial fibrillation undergoing first-time pulmonary vein isolation (PVI). All pulmonary veins (PVs) were first ablated with the 31-mm balloon size. The 28-mm balloon size was only used as bailout. Pre- and postablation left atrial ultrahigh-definition mapping was performed to assess the antral lesion area. Secondary outcome measures were procedural efficacy including balloon occlusion grade. Results Complete PVI was achieved in all 80 PVs in 20 patients (mean age 59.7 ± 10.7 years, 75% male). More than one-third of the posterior wall was ablated (35.4% ± 13.8%), and the isolated surface area was 68.7% ± 8.5%. Lateral and septal circumferential antral lesion areas were 12.1 ± 2.0 cm 2 and 19.1 ± 4.7 cm 2 , respectively. One patient demonstrated inadvertent overlap of the antral lesions on the roof. There was a trend toward lower complete balloon occlusion in the right superior PV with the 31-mm balloon size in comparison to the 28-mm size (75% and 90%, P = .08). Conclusion Cryoablation with the 31-mm size of a novel size-adjustable cryoballoon results in a large antral lesion. In small atria there is the potential for leaving a small nonablated corridor on the roof when using the 31-mm balloon in both superior PVs, which may be proarrhythmogenic.
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Boven et al. (2025) studied this question.
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