Formation of Two Classes of tRNA Synthetases in Relation to Editing Functions and Genetic Code

The genetic code is an algorithm that relates each of the20 amino acids to specific nucleotide triplets. Its origin isnot known, but any efforts to understand the developmentof the code centers on transfer RNAs and aminoacyl tRNAsynthetases. The synthetases catalyze the aminoacylationsof tRNAs that establish the algorithm of the code. In theaminoacylation reactions, each amino acid is linked to thetRNA that bears the anticodon triplet for that amino acid...