Going to the Mets: The uptake of Pt anticancer drugs also involves the Cu transporter Ctr1, which is located on the plasma membrane and contains functionally essential methionine-rich motifs. The methionine-rich peptide Mets7 reacts readily with PtII species. A striking difference between cis- and trans-[PtCl2(NH3)2] is that, upon reaction with Mets7, only the latter retains its N-donor ligands. Delivery of undegraded Pt drug to intracellular organelles by vesicle trafficking is hypothesized.
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Arnesano et al. (2007) studied this question.
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