Why the study?
Does concurrent diltiazem therapy enhance the cholesterol-lowering response to simvastatin in patients treated for CHD prevention?
Population
135 patients attending a hypertension clinic starting consecutively on simvastatin for primary or secondary…
Comparison
Simvastatin with concurrent diltiazem therapy vs Simvastatin without diltiazem
Design
Cohort
Authors
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Diltiazem co-therapy was associated with greater simvastatin-mediated cholesterol reduction; hypothesis-generating and should not yet change practice.
Does concurrent diltiazem therapy enhance the cholesterol-lowering response to simvastatin in patients treated for CHD prevention?
Concurrent diltiazem therapy significantly enhances the cholesterol-lowering effect of simvastatin, suggesting a potential need for lower simvastatin doses in these patients.
Yeo et al. (1999) studied this question.
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