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Initiation of eukaryotic protein synthesis is mediated a set of protein factors, purified using predominantly reticulocytes and Krebs II cells. At least 8 initiation factors with Mr 15000-700000 could be described. This elaborate was followed by the functional characterization the individual factors which provided considerable in the specific contribution of each factor the assembly of an initiation complex, .
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Thomas et al. (1980) studied this question.
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