Marrow-dependent cells play a crucial role in mediating genetic resistance to HSV-1 infection in mice by controlling early infection and preventing spread to the central nervous system.
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Marrow-dependent cells mediate early HSV-1 control in mice; leaves open translation to human genetic resistance or therapy.
Adult mice resistant to infection with 10(6) plaque-forming units of a virulent strain of herpes simplex virus type 1 were treated with 89Sr to abrogate marrow-dependent cell functions. Treated mice were found to be much more susceptible to the herpes simplex virus type 1 infection than untreated mice. The virus persisted in the visceral tissues of 89Sr-treated mice for 3 or more days postinfection but not in those of untreated mice. The virus also spread to the spinal cords of treated but not untreated mice. A marrow-dependent cell appeared to mediate resistance to herpes simplex virus type 1 by controlling the infection early after inoculation and not allowing the infection spread to the central nervous system.
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López et al. (1980) studied this question.
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