Polarization-sensitive optical coherence tomography is a viable method for visualizing the complex myocardial fiber architecture in mouse hearts.
Supports PSOCT for ex vivo mouse myocardial fiber mapping; leaves open in vivo and clinical translation.
We developed a method to image myocardial fiber architecture in the mouse heart using a Jones matrix-based polarization-sensitive optical coherence tomography (PSOCT) system. The "cross-helical" laminar structure of myocardial fibers can be clearly visualized using this technology. The obtained myocardial fiber organization agrees well with existing knowledge acquired using conventional histology and diffusion tensor magnetic resonance imaging.
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Wang et al. (2013) studied this question.
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