Cholera

Clinical Staff Conference1 June 1966CholeraCombined Clinical Staff Conference at the National Institutes of HealthROBERT S. GORDON JR., M.D., JOHN C. FEELEY, PH.D., WILLIAM B. GREENOUGH III, M.D., HELMUTH SPRINZ, ROBERT OSEASOHN, M.D.ROBERT S. GORDON JR., M.D.Search for more papers by this author, JOHN C. FEELEY, PH.D.Search for more papers by this author, WILLIAM B. GREENOUGH III, M.D.Search for more papers by this author, HELMUTH SPRINZSearch for more papers by this author, ROBERT OSEASOHN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1328 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Robert S. Gordon, Jr.: Cholera is an acute diarrheal disease with high mortality, if untreated. Spreading from Asia, it swept Europe with devastating pandemics in the nineteenth century (1). The conquest of cholera was one of the first triumphs of scientific medicine and did much to establish in the public mind the value of environmental sanitation. During the first half of this century, cholera received but little scientific attention, having been largely confined to its endemic home in Bengal. The past decade has seen a marked increase in both the number of cases and in the geographic areas affected....References1. POLLITZER R: Cholera. World Health Organization series no. 43. 997 pages. World Health Organization, Geneva, 1959. Google Scholar2. SHEEHYSPRINZAUGERSONFORMAL TWHWSSB: Laboratory acquired V. cholerae infection in the United States. JAMA. In press. Google Scholar3. BREEDMURRAYSMITH RSEGNR: Bergey's Manual of Determinative Bacteriology, 7th ed. The Williams & Wilkins Co., Baltimore, 1957. Google Scholar4. MCINTYREFEELEYGREENOUGHBENENSONHASSANSAAD ORJCWBASSIA: Diarrhea caused by non-cholera vibrios. Amer. J. Trop. Med. 14: 412, 1965. CrossrefMedlineGoogle Scholar5. FEELEY JC: Classification of Vibrio cholerae (Vibrio comma), including El Tor vibrios, by infrasubspecific characteristics. J. Bact. 89: 665, 1965. CrossrefMedlineGoogle Scholar6. SMITHFRETERSWEENEY HLRFJ: Enumeration of cholera vibrios in fecal samples. J. Infect. Dis. 109: 31, 1961. CrossrefGoogle Scholar7. MONSUR KA: A highly selective gelatin-taurocholate-tellurite medium for the isolation of Vibrio cholerae. Trans. Roy. Soc. Trop. Med. Hyg. 55: 440, 1961. CrossrefMedlineGoogle Scholar8. MONSUR KA: Bacteriological diagnosis of cholera under field conditions. Bull. WHO 28: 387, 1963. MedlineGoogle Scholar9. BENENSONISLAMGREENOUGH ASMRWB: Rapid identification of Vibrio cholerae by darkfield microscopy. Bull. WHO 30: 827, 1964. MedlineGoogle Scholar10. FINKELSTEINGOMEZ RACZ: Comparison of methods for the rapid recognition of cholera vibrios. Bull. WHO 28: 327, 1963. MedlineGoogle Scholar11. SACKBARUA RBD: The fluorescent antibody technique in the direct examination of cholera stool, in Proceedings of the Cholera Research Symposium. Public Health Service Publication no. 1328. U. S. Government Printing Office, Washington, D. C., 1965, p. 50. Google Scholar12. GOODNERSMITHSTEMPEN KHLH: Serologic diagnosis of cholera. J. Einstein Med. Cent. 8: 143, 1960. Google Scholar13. FEELEY JC: Comparison of vibriocidal and agglutinating antibody responses in cholera patients, in Proceedings of the Cholera Research Symposium. Public Health Service Publication no. 1328. U. S. Government Printing Office, Washington, D. C., 1965, p. 220. Google Scholar14. PHILLIPS RA: The patho-physiology of cholera. Bull. WHO 28: 297, 1963. MedlineGoogle Scholar15. FINKELSTEINNORRISDUTTA RAHTNK: Pathogenesis of experimental cholera in infant rabbits. I. Observations on the intraintestinal infection and experimental cholera produced with cell-free products. J. Infect. Dis. 114: 203, 1964. CrossrefMedlineGoogle Scholar16. BENYAJATI C: Experimental cholera in humans. Brit. Med. J. 1: 140, 1966. CrossrefMedlineGoogle Scholar17. DEGHOSECHANDRA SNMLJ: Further observations on cholera enterotoxin. Trans. Roy. Soc. Trop. Med. Hyg. 56: 241, 1962. CrossrefMedlineGoogle Scholar18. PANSEDUTTA MVNK: Excretion of toxin with stools of cholera patients. J. Infect Dis. 109: 81, 1961. CrossrefMedlineGoogle Scholar19. FINKELSTEIN RA: Immunological aspects of experimental cholera, in Proceedings of the Cholera Research Symposium. Public Health Service Publication no. 1328. U. S. Government Printing Office, Washington, D. C., 1965, p. 58. Google Scholar20. CRAIG JP: A permeability factor (toxin) found in cholera stools and culture filtrates and its neutralization by convalescent cholera sera. Nature (London) 207: 614, 1965. CrossrefMedlineGoogle Scholar21. MACLEOD K: Cholera: history and geography; morbid anatomy; and clinical features, in A System of Medicine, vol. 2, part 2, edited by ALLBUTT, T. C., ROLLESTON, H. D. Macmillan, London and New York, 1910, p. 435. Google Scholar22. OSEASOHNBENENSONFAHIMUDDIN ROASM: Field trial of cholera vaccine in rural East Pakistan. First year of observation. Lancet 1: 450, 1965. CrossrefMedlineGoogle Scholar23. ROSENBERGGREENOUGHLINDENBAUMGORDON IHWBJRS: Nutritional studies in cholera. The influence of nutritional status on susceptibility to infection, in Proceedings of the Cholera Research Symposium. Public Health Service Publication no. 1328, U. S. Government Printing Office, Washington, D. C., 1965, p. 68. Google Scholar24. LINDENBAUMGREENOUGHBENENSONOSEASOHNRIZVISAAD JWBASROSA: Non-vibrio cholera. Lancet 1: 1081, 1965. CrossrefMedlineGoogle Scholar25. GANGAROSABEISELBENYAJATISPRINZPIYARATN EJWRCHP: The nature of the gastrointestinal lesion in Asiatic cholera and its relation to pathogenesis: a biopsy study. Amer. J. Trop. Med. 9: 125, 1960. CrossrefMedlineGoogle Scholar26. FRESHVERSAGEREYES JWPMV: Intestinal morphology in human and experimental cholera. Arch. Path. (Chicago) 77: 529, 1964. MedlineGoogle Scholar27. GORDON RS: The failure of Asiatic cholera to give rise to "exudative enteropathy," in SEATO Conference on Cholera, 1960. SEATO, Bangkok, 1962, p. 54. Google Scholar28. LINDENBAUMGORDON JRS: Unpublished observations. Google Scholar29. GREENOUGHGORDONLINDENBAUM WBRSJ: Unpublished observations. Google Scholar30. HARVEYENSONLEWISGREENOUGHALLYPANNO RMYMLWBKMRA: Hemodynamic effects of dehydration and metabolic acidosis in Asiatic cholera. Trans. Ass. Amer. Physicians. In press. Google Scholar31. WATTENPHILLIPS RHRA: Potassium in the treatment of cholera. Lancet 2: 999, 1960. CrossrefMedlineGoogle Scholar32. GREENOUGHALLY WBKM: Unpublished observations. Google Scholar33. HIRSCHHORNLINDENBAUMGREENOUGHALAM NJWBSM: Hypoglycemia in children with acute diarrhea. In preparation. Google Scholar34. PHILLIPS RA: Water and electrolyte losses in cholera. Fed. Proc. 23: 705, 1964. MedlineGoogle Scholar35. PHILLIPS RA: Cholera, official method of U. S. Navy, in Current Therapy, 1964, edited by CONN, H. F. W. B. Saunders Co., Philadelphia, 1964, p. 8. Google Scholar36. CARPENTERCHAUDHURILINDENBAUMMONDALPHILLIPSABDUL WAHEDWALLACEKOBARIGORDON CCRNJARAAKCKKRS: Round table discussion: Management of patients in cholera epidemics where ideal facilities are not available, in Proceedings of the Cholera Research Symposium. Public Health Service Publication no. 1328, U. S. Government Printing Office, Washington, D. C., 1965, p. 211. Google Scholar37. GREENOUGH WB: Cholera. Method of Pakistan-SEATO Cholera Research Laboratory, in Current Therapy, 1965, edited by CONN, H. F. W. B. Saunders Co., Philadelphia, 1965, p. 7. Google Scholar38. CARPENTERCHAUDHURIMONDAL CCRNA: A simple effective therapy of cholera. Indian J. Med. Res. 52: 924, 1964. MedlineGoogle Scholar39. CARPENTERMITRASACKDANSWELLSCHAUDHURI CCPPRBPESARN: Clinical evaluation of fluid requirements in Asiatic cholera. Lancet 1: 726, 1965. CrossrefMedlineGoogle Scholar40. GREENOUGHGORDONROSENBERGDAVIESBENENSON WBRSISBIAS: Tetracycline in the treatment of cholera. Lancet 1: 355, 1964. CrossrefMedlineGoogle Scholar41. CARPENTERSACKMITRAMONDAL CCRBPPA: Tetracycline therapy in cholera. Bull. Calcutta Sch. Trop. Med. 12: 30, 1964. MedlineGoogle Scholar42. GREENOUGH WB: Pancreatic and hepatic hypersecretion in cholera. Lancet 2: 991, 1965. CrossrefMedlineGoogle Scholar43. LINDENBAUM J: Malabsorption during and after recovery from acute intestinal infection. Brit. Med. J. 2: 326, 1965. CrossrefMedlineGoogle Scholar44. SPRINZSRIBHIBHADHGANGAROSABENYAJATIKUNDELHALSTEAD HREJCDWSB: Biopsy of small bowel of Thai people. With special reference to recovery from Asiatic cholera and to an intestinal malabsorption syndrome. Amer. J. Clin. Path. 38: 43, 1962. CrossrefMedlineGoogle Scholar45. BAKERIGNATIUSMATHANVAISHCHACKO SJMVISKCC: Intestinal biopsy in tropical sprue, in Intestinal Biopsy, edited by WOLSTENHOLME, G. C., CAMERON, M. P. J. & A. Churchill, Ltd., London, 1962, p. 84. Google Scholar46. LINDENBAUM J: Personal communication. Google Scholar47. RUSSELLAZIZAHMADKENTGANGAROSA PKMANTHEJ: Enteritis and gastritis in young asymptomatic Pakistani men. Amer. J. Dig. Dis. In press. Google Scholar48. FORMALKUNDELSCHNEIDERKUNEVSPRINZ SBDHNH: Studies with Vibrio cholerae in the ligated loop of the rabbit intestine. Brit. J. Exp. Path. 42: 504, 1961. MedlineGoogle Scholar49. LABRECSPRINZSCHNEIDERFORMAL EHHHSB: Localization of vibrios in experimental cholera: a fluorescent antibody study in guinea pigs, in Proceedings of the Cholera Research Symposium. Public Health Service Publication no. 1328. U. S. Government Printing Office, Washington, D. C., 1965, p. 272. Google Scholar50. DUTTAHABBU NKMK: Experimental cholera in infant rabbits: a method for chemotherapeutic investigations. Brit. J. Pharmacol. 10: 153, 1955. Google Scholar51. OZADUTTA NBNK: Experimental cholera produced by toxin prepared by ultrasonic disintegation of Vibrio comma. J. Bact. 85: 497, 1963. CrossrefMedlineGoogle Scholar52. NORRISFINKELSTEINDUTTASPRINZ HTRANKH: Intestinal manifestations of cholera in infant rabbits—a morphologic study. Lab. Invest. 14: 1428, 1965. MedlineGoogle Scholar53. BENYAJATIKEOPLUGBEISELGANGAROSASPRINZSITPRIJA CMWREJHV: Acute renal failure in Asiatic cholera: clinicopathologic correlations with acute tubular necrosis and hypokalemic nephropathy. Ann. Intern. Med. 52: 960, 1960. LinkGoogle Scholar54. GOLDSTEINMERRILLSPRINZ HBTGH: Morphologic evidence of cytotoxicity in experimental cholera. Arch. Path. (Chicago). In press. Google Scholar55. DAMMINBENENSONFELDMANFORMALGOLDSTEINMERRILLSPRINZ GJASDSBHBTGH: Clinical and histopathologic correlations in acute diarrheal disease, in Proceedings of the Cholera Research Symposium. Public Health Service Publication no. 1328, U. S. Government Printing Office, Washington, D. C., 1965, p. 205. Google Scholar56. SPRINZ H: Current concepts of pathology and pathogenesis of cholera, in Proc. 7th Internat. Conf. Trop. Med. Malaria (Rio de Janiero, 1963) 3: 37, 1964. Google Scholar57. MERRILLSPRINZ TGH: Ultrastructural changes of intestinal capillaries in cholera. Fed. Proc. 25: 456, 1966. Google Scholar58. SNOW J: On the mode of communication of cholera (1849). Reprinted as Snow on Cholera, The Commonwealth Fund, New York. Harvard University Press, Cambridge, 1936. Google Scholar59. TENGFORBES PHGJ: The Temple Street well. WHO Cholera Information, March 1964, p. 5. Google Scholar60. OSEASOHNAHMADISLAMRAHMAN RSMAAS: Clinical and bacteriological findings among families of cholera patients. Lancet 1: 340, 1966. CrossrefMedlineGoogle Scholar61. : Interim report on the cholera El Tor studies in 1964, p. 48. Google Scholar62. FEELEYPITTMAN JCM: A mouse protection test for assay of cholera vaccine, in SEATO Conference on Cholera, 1960, SEATO, Bangkok, 1962, p. 92. Google Scholar63. PITTMANFEELEY MJC: Laboratory assay of cholera vaccine potency, in Proceedings of the Cholera Research Symposium. Public Health Service Publication no. 1328, U. S. Government Printing Office, Washington, D. C., 1965, p. 163. Google Scholar64. FEELEYPITTMAN JCM: Laboratory assays of cholera vaccine used in field trial in East Pakistan, 1963. Lancet 1: 449, 1965. CrossrefMedlineGoogle Scholar65. FRETER R: Comparison of immune mechanisms in various experimental models of cholera. Bull. WHO 31: 825, 1964. MedlineGoogle Scholar66. WATANABEVERWEY YWF: Protective antigens from El Tor vibrios. 1. The preparation and properties of a purified protective antigen from an El Tor vibrio (Ogawa subtype). Bull. WHO 32: 809, 1965. MedlineGoogle Scholar67. WATANABEVERWEYMACDONALD YWFEM: Protective antigens from El Tor vibrios. 2. Responses in animals and man to a partially purified Ogawa lipopolysaccharide antigen. Ibid., p. 823. Google Scholar68. FRETER R: Coproantibody and oral vaccines, in Proceedings of the Cholera Research Symposium. Public Health Service Publication no. 1328. U. S. Government Printing Office, Washington, D. C., 1965, p. 222. Google Scholar69. : A controlled field trial of the effectiveness of cholera and cholera El Tor vaccines in the Philippines. Bull. WHO 32: 603, 1965. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT S. GORDONJR., M.D.; JOHN C. FEELEY, PH.D.; WILLIAM B. GREENOUGHIII, M.D.; HELMUTH SPRINZ; ROBERT OSEASOHN, M.D.Affiliations: Cleveland, OhioThis is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Md., by the National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare.Requests for reprints should be addressed to Robert S. Gordon, Jr., M.D., Clinical Director, National Institute of Arthritis and Metabolic Diseases, Bldg. 10, Room 9-N-222, National Institutes of Health, Bethesda, Md. 20014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdp-Ribosylation of Guanyl Nucleotide-Binding Regulatory Proteins by Bacterial ToxinsEffects of Gastrointestinal Hormones on Adenylate Cyclase Activity in Human Jejunal MucosaCholera in Africa: A Message for the WestRICHARD W. GOODGAME, M.D., WILLIAM B. GREENOUGH III, M.D.Pathologic findings from intestinal biopsy specimens in human choleraImmunoglobulins in plasma and small intestinal fluid of cholera patientsAn electron microscopic study of the small intestine in human choleraInfectious diseases. Annual review of significant publications 1 June 1966Volume 64, Issue 6Page: 1328-1351KeywordsArmed forcesCholeraDiarrheaDysenteryGeographic areasMedical servicesMortalityPrevention, policy, and public healthSanitation ePublished: 1 December 2008 Issue Published: 1 June 1966 PDF downloadLoading ...