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Editorial
The commentary emphasizes the importance of considering various mathematical structures and careful data selection when building and comparing physiological models.
The final goal is to create mathematical models that are based on our current knowledge of the underlying physiology and that explain all of the experimental data available. To do this, we suggest a consideration of several potential mathematical structures in the formulation of models and the formal comparison of these various structures with other models in the literature. However, when making these comparisons, one must pay careful attention to the systems being modeled and the data sets chosen to represent those systems.
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Klerman et al. (1999) studied this question.
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