KV7 channels in muscle afferents regulate the exercise pressor reflex and could be a therapeutic target for patients with cardiovascular disease.
KV7 channels may modulate the exercise pressor reflex in cardiovascular disease; leaves open therapeutic targeting pending clinical studies.
K V 7 channels control neuronal excitability. We show that these channels are expressed in muscle afferents and generate currents that are blocked by XE991 and bradykinin (BK). The XE991 block suggests that K V 7 current comprises K V 7.2/3 and K V 7.5 channels. The BK inhibition of K V 7 channels may explain how BK activates the exercise pressor reflex (EPR). Retigabine can enhance K V 7 current, which could help control the inappropriately activated EPR in patients with cardiovascular disease.
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Wright et al. (2021) studied this question.
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