Effect of Vitex Agnus-Castus Ethanolic Extract and Ciprofene Citrate on Reproductive Hormones in Polycystic Ovary Syndrome in Female Rats

P olycystic ovary syndrome (PCOS) is a complex genet- ic, endocrine, and metabolic disorder, characterized by chronic anovulation, polycystic ovaries, biochemical and clinical manifestations of hyperandrogenism (Homburg, 2009).PCOS is found in approximately 4-10% of women of different reproductive age (Strowitzki et al., 2010).PCOS has a negative impact on the physiology and metabolism of the body, as it can evolve into a metabolic syndrome with insulin resistance, hyperinsulinemia, hypertension, cardiovascular disease, dyslipidemia, and abdominal obesity (Allahbadia and Merchant, 2011).PCOS is the most common gynecological endocrine disease, with a ranging from ~6% to ~20% (Escobar-Morreale, 2018).PCOS increases the risk factor for long-term metabolic disorder like type 2 diabetes mellitus (DM2) and atherosclerosis (Shi and Vine, 2012).Overweight and obesity exacerbate the reproductive and metabolic disorders of PCOS (Ching et al., 2007;Maliqueo et al., 2014).In women with PCOS, obesity is characterized mainly by accumulation of abdominal body fat.Hyperinsulinemia exists independently of obesity and therefore may be an independent factor in PCOS (Masszi et al., 2013;van Houten and Visser 2014).However, the etiology of PCOS is still obscure.One hy-