8-8-Diferulic acid (non-cyclic form) (4,4′-dihydroxy-3,3′-dimethoxy-β,β′-bicinnamic acid) was chemically synthesised and the antioxidant properties were assessed using (a) inhibition of ascorbate/iron-induced peroxidation of phosphatidylcholine liposomes, and (b) scavenging of the radical cation of ABTS (2,2′-azinobis (3-ethyl-benzothiazoline-6-sulphonate)) relative to the water-soluble vitamin E analogue, Trolox C. The structure of the chemically synthesised 8-8 dimer was confirmed by 1H-NMR and mass spectrometry. Its absorption properties in ethanol were: λmax1: 320 nm; λmax2: 287 nm; λmin: 256 nm; ελmax1 (M−1 cm−1): 14 200±1700 and ελmax2 (M−1 cm−1): 14 300±1300. The 8-8 dimer showed the best antioxidant properties in the aqueous phase assay among the esterified dimers present in plant cell walls. Like the other ferulic dimers, 8-8-diferulic acid is a better inhibitor of lipid peroxidation than ferulic acid on a molar basis. Some of the factors possibly involved in the antioxidant effect of these compounds are: number of free hydroxyl groups in the molecule, stability of transient radical and partition coefficient.
No takes yet. Share an insight, caveat, or question.
García‐Conesa et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: