Population
Human platelets loaded with the fluorescent Ca indicator quin2 and preincubated with aspirin
Design
Preclinical
Authors
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May inhibit select platelet secretory pathways at basal Ca2+ in animals; leaves open relevance to human thrombosis or antithrombotic strategies.
Trifluoperazine and chlorpromazine inhibit platelet secretion evoked by C-kinase activators at basal calcium levels, an effect that can be overcome by elevating intracellular calcium.
Sánchez et al. (1983) studied this question.
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