Answers are grounded in this paper and cite their sources.
To clarify the toxic effect of Cadmium (Cd) on bone, alkaline phosphatase (ALP) activity, which is an osteoblastic marker produced during bone formation, and DNA synthesis were examined in cultures of 21‐day old fetal rat calvaria. Both ALP activity and DNA synthesis were decreased by Cd. Probably Cd affected some stage of mineralization or cell differentiation in bone formation of calvaria. Zn coexisting in the culture medium prevented the inhibitory effect of Cd on ALP activity and DNA synthesis.
No takes yet. Share an insight, caveat, or question.
Iwami et al. (1990) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: