Pheochromocytoma: Diagnosis and Treatment

Article1 September 1949PHEOCHROMOCYTOMA: DIAGNOSIS AND TREATMENTGEORGE F. CAHILL, M.D., HENRY ARANOW JR., M.D.GEORGE F. CAHILL, M.D.Search for more papers by this author, HENRY ARANOW JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-3-389 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPheochromocytomas are relatively rare tumors of the chromaffin sympathetic nerve tissue, usually producing epinephrine, and/or, norepinephrine and most often seen in the adrenal medulla or in one of the many areas where chromaffin tissue occurs.1, 2The usual symptoms produced by the tumor are the result of the secretion of an excess of epinephrine or some other allied pressor substance, either intermittently or continuously. The action of epinephrine is hemodynamic and metabolic. The hemodynamic changes have a short latent period, a dependence of the magnitude of response upon the dose, and a rapid return to normal. They are a constriction...Bibliography1. HOLTEN P: Noradrenaline in adrenal medullary tumors, Nature, 1949, clxiii, 217. CrossrefGoogle Scholar2. GOLDENBERGFABERALSTONCHARGAFF MMEJEC: Evidence of the occurrence of norepinephrine in the adrenal medulla, Science, 1949, cix, 534. CrossrefGoogle Scholar3. BEERKINGPRINZMETAL EFM: Pheochromocytoma with demonstration of a pressor substance in the blood, Ann. Surg., 1937, cvi, 85. CrossrefGoogle Scholar4. BAUERBELT JE: Paroxysmal hypertension with concomitant swelling of the thyroid due to pheochromocytoma of the right adrenal gland. Cure by surgical removal of the pheochromocytoma, Jr. Clin. Endocrin., 1947, vii, 30. CrossrefGoogle Scholar5. ROWNTREEBALL LGRG: Diseases of suprarenal glands, Endocrinology, 1933, xvii, 263. CrossrefGoogle Scholar6. WELLSBOMAN AHPG: Clinical and pathological identity of pheochromocytoma, Jr. Am. Med. Assoc., 1937, cix, 1177. Google Scholar7. VAN EPPSHYNDMANGREENE EFORJA: Clinical manifestations of paroxysmal hypertension associated with a pheochromocytoma of adrenal. Report of proved and doubtful cases, Arch. Int. Med., 1940, lxv, 1123. CrossrefGoogle Scholar8. PENFIELD W: Diencephalic antonomic epilepsy, Arch. Neurol. and Psychiat., 1929, xxii, 358. CrossrefGoogle Scholar9. GREEN DN: Pheochromocytoma and chronic hypertension, Jr. Am. Med. Assoc., 1946, cxxxi, 1260. CrossrefGoogle Scholar10. GOLDENBERGSNYDERARANOW MCHH: New test for hypertension, Jr. Am. Med. Assoc., 1947, cxxxv, 971. CrossrefGoogle Scholar11. THORNHINDLESANDMEYER GWJAJA: Pheochromocytoma of the adrenal associated with persistent hypertension, Ann. Int. Med., 1944, xxi, 122. Google Scholar12. PALMERCASTLEMAN RSR: Paraganglioma (chromaffinoma, pheochromocytoma) of adrenal gland simulating malignant hypertension. Report of case, New England Jr. Med., 1938, ccix, 793. CrossrefGoogle Scholar13. BINGERCRAIG NWWM: An atypical case of hypertension with tumor of the adrenal gland, Proc. Staff Meet. Mayo Clin., 1938, xiii, 17. Google Scholar14. PHILLIPS R: Intrathoracic pheochromocytoma, Arch. Path., 1940, xxx, 916. Google Scholar15. KIRSCHBAUMBALKIN JDRB: Adrenalin-producing pheochromocytoma of the adrenal associated with hypertension. Report of three cases, Ann. Surg., 1942, cxvi, 54. CrossrefGoogle Scholar16. MCCULLAGHENGEL EPWJ: Pheochromocytoma with hypermetabolism. Report of two cases, Ann. Surg., 1942, cxvi, 61. CrossrefGoogle Scholar17. GANEMCAHILL EJGF: Pheochromocytomas, coexisting in adrenal gland and retroperitoneal space with sustained hypertension, New England Jr. Med., 1948, ccxxxviii, 692. CrossrefGoogle Scholar18. CAHILL GF: Pheochromocytomas, Jr. Am. Med. Assoc., 1948, cxxxviii, 180. CrossrefGoogle Scholar19. DUNCANSEMANSHOWARD LEJHJE: Adrenal medullary tumor (pheochromocytoma) and diabetes mellitus. Disappearance of diabetes after removal of tumor, Ann. Int. Med., 1944, xx, 815. Google Scholar20. ENGLEMENCHERENGEL FLWHGL: "Epinephrine shock" as manifestation of pheochromocytoma of adrenal medulla. Report of case with successful removal of tumor, Am. Jr. Med. Sci., 1942, cciv, 649. Google Scholar21. DEVRIESRACHMILEWITZSCHUMER AWM: Pheochromocytoma with diabetes and hypertension, Am. Jr. Med., 1949, vi, 51. CrossrefGoogle Scholar22. ERNOULDPICARD HE: Un cas de sympathome sympathogonique avec hypertension arterielle paroxystique, Rev. belge sc. méd., 1934, vi, 223. Google Scholar23. KREUZFELDT : Attempts to demonstrate the presence of pressor substances in the blood of patients with renal hypertension, Acta med. Scandinav., 1946, cxxv, 171. Google Scholar24. SPEARGRISWOLD HCD: The use of dibenamine in pheochromocytoma. Report of a case, New Eng. Jr. Med., 1948, ccxxxix, 737. Google Scholar25. ROTHKVALE GMWF: Tentative test for pheochromocytoma, Am. Jr. Med. Sci., 1945, ccx, 653. CrossrefGoogle Scholar26. COLSTON JA: Surgical aspects of bilateral familial pheochromocytoma, Trans. Am. Assoc. G. U. Surg., 1947, xxxix, 81. Google Scholar27. GUARNERIEVANS VJA: Pheochromocytoma. Report of a case with a new diagnostic test, Am. Jr. Med., 1948, iv, 806. CrossrefGoogle Scholar28. EWART E: Discussion, Jr. Am. Med. Assoc., 1948, cxxxviii, 186. Google Scholar29. LADUEMURISONPACK JSPJGT: The use of tetraethyl ammonium bromide as a diagnostic test for pheochromocytoma, Ann. Int. Med., 1948, xxix, 914. Google Scholar30. HOWARDBARKER JEWH: Paroxysmal hypertension and other clinical manifestations associated with benign chromaffin cell tumors (pheochromocytoma), Bull. Johns Hopkins Hosp., 1937, lxi, 371. Google Scholar31. CAHILL GF: Hormonal tumors of the adrenal, Surgery, 1944, xvi, 233. Google Scholar32. MENCHER WH: Perirenal insufflation, Jr. Am. Med. Assoc., 1937, cix, 1338. CrossrefGoogle Scholar33. MAYER H: Personal communication. Google Scholar34. HUMPHREYS GN: Personal communication. Google Scholar35. HECHTANDERSON HHRB: The influence of dibenamine (NN-dibenzyl-β-chloroethylamine) on certain functions of the sympathetic nervous system, Am. Jr. Med., 1947, iii, 3. CrossrefGoogle Scholar36. BISKINDMEYERBEADNER GRMSA: Adrenal medullary tumor. Pheochromocytoma cured by surgical intervention, Jr. Clin. Endocrin., 1941, i, 113. CrossrefGoogle Scholar37. GOLDENBERGAPGARDETERLINGPINES MVRAVL: Norepinephrine as a pressor drug, Jr. Am. Med. Assoc., 1949, cxl, 776. CrossrefGoogle Scholar38. GOLDENBERGPINESBALDWINGREENEROH MVLEDDGCE: The hemodynamic response of man to norepinephrine and epinephrine and the relation to the problem of hypertension, Am. Jr. Med., 1948, v, 792. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Presented at the Thirtieth Annual Session of the American College of Physicians, March 29, 1949, New York, N. Y.From the Departments of Urology and Medicine, Columbia-Presbyterian Medical Center, New York City. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPHEOCHROMOCYTOMAPhæOchromocytoma a report of two cases with a review of the diagnostic testsPlasma normetanephrine measurements for detection of pheochromocytoma in patients with hypertensionA simple and specific radioenzymatic assay for measurement of urinary normetanephrineThe biochemical techniques for detecting and establishing the presence of a pheochromocytomaPheochromocytoma with nephrotic syndromeThe Diagnosis and Management of PhaeochromocytomaDie Chirurgie des RetroperitonealraumesPHEOCHROMOCYTOMASurgery of the adrenalsSome uses for presacral oxygen insufflationNeoplastic diseaseNeoplastic diseasePHEOCHROMOCYTOMA ASSOCIATED WITH PAINLESS MYOCARDIAL INFARCTION*MARTIN H. BOLDT, M.D., F.A.C.P., MORRIS FLEXNER, M.D., F.A.C.P., ALVIN B. ORTNER, M.D., F.A.C.S.Paroxysmal Hypertension Due to PheochromocytomaPHEOCHROMOCYTOMA: THE VALUE OF CERTAIN TESTS USED ROUTINELY IN DIAGNOSIS*EDWARD S. ORGAIN, M.D., F.A.C.P.Value and Limitation of Roentgenographic Diagnosis of Adrenal DiseasePHEOCHROMOCYTOMA: TWO CASE REPORTS WITH UNUSUAL REACTIONS AND A GENERAL REVIEW*CHARLIE F. WINGO, M.D., JOHN P. WILLIAMS, M.D., F.A.C.P., FRANK A. WADE, M.D.Die Keimdrüsen und ihre KrankheitenPHAEOCHROMOCYTOMA OF THE SUPRARENAL GLANDOffice Diagnosis of PheochromocytomaCONTROL OF BLOOD-PRESSURE IN OPERATION FOR PHÆOCHROMOCYTOMAThe localization of ph˦ochromocytomasAN UNUSUAL CASE OF PHEOCHROMOCYTOMA WITH FATAL OUTCOME*NORMAN O. ROTHERMICH, M.D., F.A.C.P.Pheochromocytoma with false negative benzodioxane testsMultifocal ventricular tachycardia induced by etamon in a case of pheochromocytomaPheochromocytoma: Report of a Malignant Case (Pheochromoblastoma)The Use of Dibenamine and Norepinephrine in the Operative Treatment of PheochromocytomaUntoward Reactions to Tests for Epinephrine-Secreting Tumors (Pheochromocytoma) 1 September 1949Volume 31, Issue 3Page: 389-404KeywordsEpinephrineHemodynamicsNervesNorepinephrinePheochromocytomaUrology Issue Published: 1 September 1949 Copyright & PermissionsCopyright, 1949, by The American College of PhysiciansPDF downloadLoading ...