Why the study?
To validate whether the rotavirus VP4 rearrangement inserts a C-terminal segment into target cell membranes, enabling Ca 2+ permeabilization during viral entry.
Population
Liposome-attached virions (triple-layer particles: TLPs)
Design
In vitro cryo-EM and single-particle fluorescence imaging study
Authors
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Supports VP5* insertion as driver of Ca2+ leak in rotavirus entry; leaves open antiviral targeting of this transition.
The study provides a molecular description of early events in rotavirus entry, showing how the VP5*/VP8* conformational transition permeabilizes membranes to Ca2+.
Sautu et al. (2023) studied this question.
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