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). Furthermore, we show that the diazirine-based probes can also be used to identify enzymes that catalyse the removal of histone lysine acetylation and malonylation. This study provides new chemical tools for examining PTM-mediated protein-protein interactions and broadens the scope of our photo-cross-linking strategy from finding histone PTM 'readers' to identifying dynamic and transient interactions between PTMs and their 'erasers'.
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Yang et al. (2014) studied this question.
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