Why the study?
Does high dose (40 mg) enoxaparin increase pericardial effusion rates or mortality in patients undergoing proximal thoracic aortic surgery compared to low dose (20 mg) enoxaparin?
Population
189 patients who underwent proximal thoracic aortic surgery.
Comparison
High dose (40 mg) subcutaneous enoxaparin vs Low dose (20 mg) subcutaneous enoxaparin
Design
Cohort
Follow-up
up to one year
Authors
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May support 40 mg enoxaparin use without excess effusion risk after aortic surgery; observational data leave causality and mortality effects open.
Does high dose (40 mg) enoxaparin increase pericardial effusion rates or mortality in patients undergoing proximal thoracic aortic surgery compared to low dose (20 mg) enoxaparin?
Adoption of the NICE-recommended 40 mg enoxaparin thromboprophylaxis regimen does not significantly increase pericardial effusion rates after proximal thoracic aortic surgery compared to a 20 mg regimen.
Rahman et al. (2013) studied this question.
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