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The reaction of 2‐chloromethylquinazoline 3‐oxides (3) with the anion of nitromethane gave the 2‐nitromethylene benzodiazepine oxides (4) as a result of ring expansion. Other nucleophiles led only to products derived from substitution of the halogen. The ring expansion of 2,2‐dichloro‐1,2‐dihydroquinazolines with nitromethane anion is also described.
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Fryer et al. (1976) studied this question.
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