Why the study?
Obesity increases cardiovascular morbidity and mortality, altering bone marrow homeostasis and promoting a prothrombotic state through dysregulated platelet activation.
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Design
Review
Obesity heightens thrombosis risk via platelet and marrow dysregulation; extends mechanistic understanding but leaves open targeted therapies for validation.
Obesity is a major health issue that can increase the risk of cardiovascular morbidity and mortality. Obesity is characterized by an elevated prothrombotic state in which dysregulated platelet activation is a major component due to accumulation of adipose depots, insulin resistance, endothelial dysfunction, low-grade chronic inflammation and oxidative stress. Obesity also alters the homeostasis of the bone marrow, the site where megakaryopoiesis and platelet production take place, which include bone marrow adipose tissue as an important constituent of this microenvironment. Here, we provide an up-to-date review focusing on bone marrow adipose tissue and the influence of obesity on megakaryocytes and platelets that increases the cardiovascular risk.
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Vauclard et al. (2022) studied this question.
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