Key result
Myocardial ischemia decreases water proton relaxation times and hydration in isolated cardiac mitochondria.
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Nuclear magnetic resonance studies of mitochondria isolated from ischemic hearts after coronary vessel occlusion indicated a decrease in water proton relaxation times. This change coincided with a decrease in the hydration of the samples. It is suggested that in ischemia, changes in macromolecular hydration may be one of the first mechanisms to alter function in the mitochondria, which are vital to the energy-transducing process in heart muscle.
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Michael et al. (1980) studied Myocardial ischemia. Coronary vessel occlusion was evaluated on Water proton relaxation times and hydration in isolated cardiac mitochondria. Coronary vessel occlusion-induced myocardial ischemia decreased water proton relaxation times and hydration in isolated cardiac mitochondria.
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