Associations of anaemia with bleeding and thrombotic complications in patients with atrial fibrillation treated with warfarin: a registry-based nested case–control study

Figures

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  Figure 1. Laboratory measurements and the OR for bleeding events, with 95% CIs. Only statistically significant results are shown. The OR 1.0 of reference group is depicted with a dashed line. The number of cases and controls, and more detailed results in each group are provided in the online supplemental table 1. ALT, alanine aminotransferase; Crea, creatinine; Hgb, haemoglobin; Leuk, leucocytes.

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  Figure 2. Laboratory measurements and the OR for stroke/TIA events, with 95% CIs. Only statistically significant results are shown. The OR 1.0 of reference group is depicted with a dashed line. The number of cases and controls, and more detailed results in each group are provided in the online supplemental table 2. ALT, alanine aminotransferase; Crea, creatinine; Hgb, haemoglobin; Leuk, leucocytes; TIA, transient ischaemic attack.

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  Figure 3. Significantly different laboratory test results among the controls (n=14 042) and the patient cases (n=4681) having a bleeding event (white background plots). For the patients with stroke/TIA, the box plots of the controls (n=14 063) and the stroke/TIA cases (n=4692) are shown (grey background plot). The INR levels (p for difference=0.98 for bleeding cases and p<0.001 for stroke cases) and clinically significant changes in haemoglobin and creatinine (p<0.001) laboratory values are shown. For INR, the treatment range 2.0–3.0 is shown with the dashed line. For haemoglobin, the reference interval lower limit and for creatinine, reference interval upper limit are shown with continuous and dotted lines for women and men, respectively. Box plots depict ranges (whiskers), quartiles 1 and 3 (box limits) and medians (horizontal line). The n-values in the figure represent the number of patients who had a laboratory result. For the data with corresponding p values, please see online supplemental table 3, and for the entire dataset, online supplemental tables 4 and 5. INR, international normalised ratio; TIA, transient ischaemic attack.