It was demonstrated by the present study that glycyrrhizin inhibited the action of estradiol-17β on uterine weight and β-glucuronidase activity in ovariectomized mice and rats in a certain dose ratio. The inhibition was 50% or more when the dose ratio of glycyrrhizin: estradiol-17β was 1000: 1. In any higher ratio of glycyrrhizin to estrogen, the inhibition was decreased or even reversed. Glycyrrhizin by itself had no effect on either uterine weight or β-glucuronidase activity in ovariectomized mice. The mechanism of the anti-estrogenic effect was discussed in relation to the effect of glycyrrhizin on biological actions and hepatic degradation of cortisone.
No takes yet. Share an insight, caveat, or question.
Kumagai et al. (1967) studied this question.