A fluorescently labeled DNA molecule is end tethered to a small magnetic bead and pulled by a calibrated magnetic force through a solution of unlabeled DNA molecules to monitor the transport coefficients of the chain. From the force velocity diagram F-V, we report the first direct measurement of the friction coefficient ζ0ex0ex=0ex0exF/V of a single DNA molecule. ζ is found to be highly velocity dependent due to sharp conformational transitions for increasing velocities in agreement with a recent model by Ajdari et al. [Physica (Amsterdam) 204A, 17 (1994)].
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Denis Wirtz (1995) studied this question.
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