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August 1, 1992Journal of Biological ChemistryOpen Access

Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3‘-azido-3‘-deoxythymidine.

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Authors

SLSimon F. LaceyResearch Triangle Park FoundationJRJohn E. ReardonUniversity of IowaEFEric S. FurfineIndiana University Health

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Lacey et al. (1992) studied this question.

synapsesocial.com/papers/6a7122ebe5469ee92be1bf4dhttps://doi.org/10.1016/s0021-9258(19)49604-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mutants of feline immunodeficiency virus resistant to 3'-azido-3'-deoxythymidine1991 · 80 citations
  2. 2Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.1986 · 1,356 citations
  3. 3Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)1989 · 1,175 citations
  4. 4Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities.1991 · 179 citations
  5. 5The Safety and Efficacy of Zidovudine (AZT) in the Treatment of Subjects with Mildly Symptomatic Human Immunodeficiency Virus Type 1 (HIV) Infection1990 · 606 citations