Performance of a protein biomarker panel for prediction of cardiovascular events in patients with diabetes mellitus

Persons with diabetes mellitus (DM) are at increased risk of cardiovascular events (CVEs).1 Pathophysiological processes leading to CVE such as acute myocardial infarction (MI), stroke, or cardiovascular (CV) death may be inherently different in persons with DM compared with those without. Therefore, an improved risk assessment for individuals with diabetes is needed, particularly for those at higher risk for events such as those undergoing angiographic evaluation for CV disease. One option might be a biomarker-leveraged approach for the prediction of risk. For the present analysis, we utilized the resources of the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) cohort study (NCT00842868). In brief, patients undergoing coronary and/or peripheral angiography, with or without intervention, between 2008 and 2011 were prospectively enrolled at the Massachusetts General Hospital in Boston, MA, USA and were followed for occurrence of clinical outcomes until 2015.2 In this post hoc analysis, we evaluated the...