Why the study?
Do statins improve perioperative morbidity and mortality?
Do statins improve perioperative morbidity and mortality?
This review highlights the potential beneficial pleiotropic effects of statins on perioperative morbidity and mortality.
May support perioperative statin use; leaves open confirmation via prospective RCTs.
Statins belong to a specific group of drugs that have been described for their ability to control hyperlipidemia as well as for other pleiotropic effects such as improving vascular endothelial function, inhibition of oxidative stress pathways, and anti-inflammatory actions. Accumulating clinical evidence strongly suggests that statins also have a beneficial effect on perioperative morbidity and mortality. Therefore, this review aims to present all recent and pooled data on statin treatment in the perioperative setting as well as to highlight considerations regarding their indications and therapeutic application.
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Galyfos et al. (2017) studied this question.
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