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I wish to comment on the commentary by Grajower et al. (1) regarding how long insulin should be used once a vial is started. I agree with Dr. Grajower that this is an important issue, and I am glad that Dr. Mayer Davidson and Diabetes Care have chosen to obtain responses from the American Diabetes Association and the pertinent pharmaceutical manufacturers of insulin. However, I found the responses from Aventis, Eli Lilly, and Novo Nordisk to be totally unsatisfactory and self-serving. Although Aventis provides data showing stability for 4 weeks, it does not provide data …
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Mark E. Molitch (2004) studied this question.
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