The malignant neurogenic rat cell line BT4C developed tolerance to further heat injury after continuous heating in culture at 41.0 and 42.0 degrees C for 8 and 2 hours, respectively. Survival was evaluated by colony forming ability. The proliferative capacity of the surviving cells was reduced after heating as shown by a decrease in size of the colonies.
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Olav Dahl (1980) studied this question.
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