Population
Rat myocardium models
Comparison
In vivo transfection with reporter gene… vs Transfection with the previously cloned 3.6 kb…
Design
Preclinical
Authors
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May warrant re-evaluation of ANP promoter models in hypertrophy; leaves open therapeutic targeting of upstream silencers pending human validation.
The identification of novel silencer elements in the upstream rat ANP promoter suggests that the functional significance of regulatory elements within the proximal promoter region for ANP upregulation in left ventricular hypertrophy needs re-evaluation.
Mayer et al. (2002) studied this question.
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