Despite established control measures, the large-scale use of veterinary biologicals may involve side-effects. The most common side-effects observed include the following: injection site reactions, systemic reactions, allergic reactions, effects on the immune system, residual pathogenicity, inadequate inactivation, genetic recombination, contamination. New technologies, new harmonised regulations, and commitment to quality will ensure a continuous supply of safe and innovative products.
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S Martinod (1995) studied this question.
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