The asymmetric Strecker reaction of aldimines and trimethylsilyl cyanide promoted by 1 equivalent of chiral N-oxide affords the corresponding a-amino nitriles with enantioselectivities of Up to 73% most effectively for electron-deficient aldimines under mild reaction conditions. Two new resolving methods and one new synthetic methodology were developed to obtain three novel chiral N-oxides.
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Liu et al. (2001) studied this question.