FPGA-Controlled All-Solid-State Nanosecond Pulse Generator for Biological Applications

In vivo studies of tumor-cell apoptosis induced by nanosecond pulsed electric field require high-voltage nanosecond pulses delivered to the biological tissues. In this paper, a newly developed all-solid-state nanosecond pulse generator based on the Marx generator concept is proposed for this application. The generator comprises four parts: a dc charging power, a solid-state Marx circuit using metal-oxide-semiconductor field-effect transistors, a control circuit using a field-programmable gate array, and the load. This generator has the capability of producing repetitive pulses with a voltage up to 8 kV, pulsewidth of 200-1000 ns, rise time of 35 ns, and repetition rate of 1-1000 Hz with various resistive loads and 1-kV dc input voltage. The all-solid-state design makes the generator compact and reliable. Initial experiments were carried out to verify the performances of the proposed generator.