Population
isolated perfused embryonic chick ventricles (16-21 days old)
Comparison
low pH exposure vs normal pH
Design
Preclinical
Authors
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Acidic pH may selectively suppress slow inward currents in myocardium; hypothesis-generating for arrhythmia modulation, pending in vivo validation.
Acidic pH selectively blocks the slow inward current in myocardial tissue, causing electromechanical uncoupling without blocking the fast Na+ current.
Vogel et al. (1977) studied this question.
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