The Influence of Small Functional Bladder Capacity and and Other Predictors on the Response to Desmopressin in the Management of Monosymptomatic Nocturnal Enuresis

No AccessJournal of UrologyIncontinence1 Aug 1996The Influence of Small Functional Bladder Capacity and and Other Predictors on the Response to Desmopressin in the Management of Monosymptomatic Nocturnal Enuresis H.Gil Rushton, A.Barry Belman, Mark R. Zaontz, Steven J. Skoog, and Stephen Sihelnik H.Gil RushtonH.Gil Rushton , A.Barry BelmanA.Barry Belman , Mark R. ZaontzMark R. Zaontz , Steven J. SkoogSteven J. Skoog , and Stephen SihelnikStephen Sihelnik View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65775-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The relationship of functional bladder capacity as well as other variables to the responsiveness to desmopressin in children with monosymptomatic nocturnal enuresis was investigated. Materials and Methods: A total of 95 children 8 to 14 years old with monosymptomatic nocturnal enuresis (6 or more of 14 nights wet) were evaluated in a double-blind study followed by open label crossover extension using 20 to 40 mcg. desmopressin. Evaluated predictors of response included patient age, gender, race, family history, number of baseline wet nights, urine osmolality parameters and maximum functional bladder capacity (as a percent of predicted bladder capacity based on the formula, patient age + 2 × 30 = cc). Responders to desmopressin were classified as excellent (2 or less of 14 nights wet) or good (50 percent or greater decrease but more than 2 of 14 nights wet) and nonresponders were defined by a less than 50 percent decrease in wet nights. Results: Of the 95 patients 25 (29.5 percent) achieved an excellent response to desmopressin and 18 (18.9 percent) had a good response for a cumulative response rate of 45.3 percent. 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Volume 156Issue 2SAugust 1996Page: 651-655 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information H.Gil Rushton More articles by this author A.Barry Belman More articles by this author Mark R. Zaontz More articles by this author Steven J. Skoog More articles by this author Stephen Sihelnik More articles by this author Expand All Advertisement PDF downloadLoading ...