Systems biology of polycystic kidney disease: a critical review

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The proliferation and diminishing costs of ‘omics’ approaches have finally opened the doors for small and medium laboratories to enter the ‘systems biology era’. This is a welcome evolution that requires a new framework to design, interpret, and validate studies. Here, we highlight some of the challenges, contributions, and prospects of the ‘cyst‐ems biology’ of polycystic kidney disease. WIREs Syst Biol Med 2015, 7:39–52. doi: 10.1002/wsbm.1289 This article is categorized under: Analytical and Computational Methods > Computational Methods Laboratory Methods and Technologies > Genetic/Genomic Methods Translational, Genomic, and Systems Medicine > Translational Medicine