Present study is designed to evaluate the effect of Hesperidin, a naturally occurring citrus flavanone isolated from orange peels, against cisplatin-induced nephrotoxicity. Nephroprotector activity was evaluated in male Albino rats. Nephrotoxicity induced by intraperitoneal administration (6 mg/kg,i.p., single dose) of cisplatin. Hesperidin was administered by gastric intubation. Nephroprotector activity of hesperidin was tested at two dose levels i.e., 200mg and 400mg/kg Body weight. Nephrotoxicity was assessed by estimating blood urea nitrogen, serum creatinine and estimating urinary parameters. Cisplatin nephrotoxicity was characterized by elevated levels of blood urea nitrogen, serum creatinine, and high protein excretion in urine and reduced levels of creatinine clearance. Hesperidin produced significant protection against cisplatin – induced nephrotoxicity in dose dependent manner.
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Spandana et al. (2016) studied this question.