Key result
HDL-C-raising interventions (lifestyle modifications, niacin, fibrates) are reviewed for their antiatherogenic effects against coronary heart disease.
Population studies have consistently demonstrated an inverse association between HDL-C and the risk of coronary heart disease. As a result, HDL-C is gaining increasing interest as a therapeutic target. In this article, we review the mechanism of action for the postulated antiatherogenic effect of HDL-C and how current and future therapies can exploit this beneficial activity. The clinical evidence supporting various interventions to raise HDL-C, from lifestyle modifications to established drugs (e.g., niacin and fibrates) is reviewed. Finally, we discuss new and promising approaches to enhance HDL-C.
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Santos‐Gallego et al. (2011) conducted a review in Atherosclerosis and coronary heart disease. HDL-C-raising therapies (lifestyle modifications, niacin, fibrates, novel approaches) was evaluated on Coronary heart disease and atherosclerosis. HDL-C-raising interventions (lifestyle modifications, niacin, fibrates) are reviewed for their antiatherogenic effects against coronary heart disease.
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