A heterogeneous chiral sensor for DNA detection is demonstrated by post-assembly system reconfiguration for two types of NPs pyramids. In the presence of target DNA, two types of NPs pyramids undergo dynamic reconfiguration or dissociation process which functions as an off-on or on-off switch towards CD signals changes. Under optimized conditions, the detection limit of this approach can reach to 3.4 aM with no involvement of amplification process.
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Yan et al. (2014) studied this question.
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