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The effects of vitamin A and hydrocortisone on the immune response have been studied in the mouse. Vitamin A treatment alone markedly increases the normal number of antibody-forming cells generated in the spleen in response to immunization with sheep red blood cells. The antibody response to immunization with dinitrophenylated ovalbumin (DNP-OVA), a hapten-protein conjugate, is also enhanced by vitamin A pretreatment. Furthermore, the immunosuppressive effect of hydrocortisone on the response to sheep red blood cells can be prevented by simultaneous administration of vitamin A.
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Cohen et al. (1973) studied this question.
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