Antithrombic and anti-atherogenic effects of partially defatted flaxseed meal using a laser-induced thrombosis test in apolipoprotein E and low-density lipoprotein receptor deficient mice
Animal study demonstrates that partially defatted flaxseed meal reduces thrombosis and atherogenesis in hyperlipidemic mice, indicating dietary benefits against atherothrombosis.
Key Points
To evaluate the protective effects of partially defatted flaxseed meal and the flaxseed lignan secoisolariciresinol diglucoside on thrombus formation and atherogenesis.
Apolipoprotein E and low-density lipoprotein receptor-deficient mice were fed a 40% energy high-fat diet with 0.05% cholesterol for 8 weeks.
Mice were assigned to control diet, diet with 5% w/w partially defatted flaxseed meal (8.3 g/kg body weight per day), or diet with 0.06% w/w secoisolariciresinol diglucoside (100 mg/kg body weight per day).
Thrombotic and atherosclerotic status was measured using a quantitative laser-induced thrombus formation assay in the carotid artery.
Partially defatted flaxseed meal produced significant antithrombotic (P < 0.01) and anti-atherogenic (P < 0.01) effects compared to the control diet.
Secoisolariciresinol diglucoside supplementation showed no significant effect on either atherogenesis or thrombus formation.