Measurement of Intima-Media Thickness Depending on Intima Media Complex Segmentation by Deep Neural Networks

Intima Media Thickness (IMT) of the carotid artery is an important marker indicating the sign of cardiovascular disease. Automated measurement of IMT requires segmentation of intima media complex (IMC).Traditional methods which use shape, color and texture for classification have poor generalization capability. This paper proposes two models- the pipeline model and the end-to-end model using Convolutional Neural Networks (CNN) and auto encoder–decoder network respectively. CNN architecture is implemented and tested by varying the number of convolutional layer, size of the kernel as well as the number of kernels. Auto encoder–decoder performs pixel wise classification using two interconnected pathways for identifying the boundary of lumen-intima (LI) and media adventitia (MA). This helps in reconstruction of the segmented portion for measurement of IMT. Both methods are tested using a dataset of 550 subjects. The results clearly indicate that end-to-end model has an edge over the pipeline model exhibiting lesser deviation between the automated measurement and the measurement made by the radiologist. The pipeline model however has better segmentation accuracy when the size of the image used for training is small. The convolutional neural network with auto encoder–decoder proves robust through sparse representation, and faster learning with better generalization. Also, the experimental setup is analyzed by interconnecting Tensor flow simulated result with Raspberry PI and the outcomes are analyzed.