What question did this study set out to answer?

To evaluate whether oral dehydroepiandrosterone (DHEA) administration modifies glucose, insulin, and beta-endorphin secretion in response to an oral glucose challenge across early and late postmenopausal women.

April 2, 2019Gynecological EndocrinologyOpen Access

Oral dehydroepiandrosterone restores ß-endorphin response to OGTT in early and late postmenopause

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Authors

AGAndrea GianniniUniversity of Pisa AGAlessandro D. GenazzaniUniversity of Modena and Reggio Emilia ANAntonio NapolitanoRoyal Marsden Hospital

Discussion

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Implication

Interventional study demonstrates oral DHEA restores beta-endorphin response during glucose tolerance testing in postmenopausal women, suggesting improved neuroendocrine regulation.

Key Points

To evaluate whether oral dehydroepiandrosterone (DHEA) administration modifies glucose, insulin, and beta-endorphin secretion in response to an oral glucose challenge across early and late postmenopausal women.
Conducted an interventional trial in 46 healthy postmenopausal women divided into four groups based on menopausal timing and body mass index: early postmenopausal (50–55 years) normal weight (group A, n=12) and overweight (group B, n=12), plus late postmenopausal (60–65 years) normal weight (group C, n=11) and overweight (group D, n=11).
Administered oral DHEA at 50 mg/day over a 6-month period.
Evaluated plasma hormone dynamics using area under the curve (AUC) measurements during oral glucose tolerance tests (OGTT) at baseline, 3 months, and 6 months.
Older postmenopausal women demonstrated lower baseline plasma levels of DHEA, DHEAS, and beta-endorphin compared to younger postmenopausal women.
Across all four groups, the AUC of beta-endorphin in response to OGTT showed progressive, statistically significant increases at 3 months and further increases at 6 months compared to baseline and 3-month evaluations.

Cite This Study

Giannini et al. (2019) studied this question.

synapsesocial.com/papers/6a7147a4e5469ee92be1dc49 https://doi.org/10.1080/09513590.2019.1590548

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Implication

Interventional study demonstrates oral DHEA restores beta-endorphin response during glucose tolerance testing in postmenopausal women, suggesting improved neuroendocrine regulation.

Oral dehydroepiandrosterone restores ß-endorphin response to OGTT in early and late postmenopause

Discussion

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Implication

Key Points

Cite This Study

Oral dehydroepiandrosterone restores ß-endorphin response to OGTT in early and late postmenopause

Discussion

Member takes

Implication

Key Points

Cite This Study

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