An Expedient Synthesis of Novel Derivatives of Pyrido[2,3‐d]pyrimidines Using Magnetically Supported ZrO₂ Nanocatalyst

An efficient synthesis of pyrido[2,3‐ d ]pyrimidine derivatives via one‐pot multicomponent reactions of 6‐amino‐2‐(alkylthio)pyrimidin‐4(3 H )‐one, 3‐cyanoacetylindole and arylaldehydes using [Fe 3 O 4 @ZrO 2 ] as magnetically recyclable nanocatalyst is reported. This protocol furnished the desired products in good to excellent yields (70–93 %) and lower reaction times. The catalyst could be easily and efficiently separated from the final product solution by an external magnet and be reused in 5 consecutive runs without any significant activity decrease.