Dynamic Kinetic Resolution Allows a Highly Enantioselective Synthesis of cis‐α‐Aminocycloalkanols by Ruthenium‐Catalyzed Asymmetric Hydrogenation

Resolutely dynamic hydrogenation: A highly efficient asymmetric hydrogenation of racemic N,N-disubstituted α-aminocycloalkanones involving dynamic kinetic resolution in the presence of a ruthenium catalyst gives chiral α-aminocycloalkanols with excellent enantioselectivities and cis diastereoselectivities (see scheme). A synthesis of optically pure U-(−)-50488 based on this reaction is reported.