Blood volume studies with the use of IHSA 131I were done on 25 normal children and 25 children with sickle cell anemia. Values which appeared to be significantly different when related to weight were no longer different when related to height. The best correlation was obtained when log blood volume was related to log height. Study of this relationship indicated that there was no significant volume difference between the anemic and normal children. Since volume relates best to lean body mass or to body water, the use of body weight alone as the basis for its determination will be inaccurate in individuals whose weights deviate from normal, if this deviation is clue essentially to fat. Thus, previous studies of high volume values in anemic children were probably related to the use of weight as the reference parameter. The following formula is recommended to calculate blood volume based on height: log B.V. = 0.247 + 2.14 log Ht.
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Gross et al. (1971) studied this question.