Why the study?
Does LDL inhibit the Na+/H+ antiport in human platelets and augment platelet reactivity?
Population
Human platelets and platelets from patients with familial hypercholesterolemia
Comparison
Incubation with physiological concentrations of… vs Untreated platelets or pre-apheresis state
Design
Preclinical
Authors
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May augment platelet reactivity in hypercholesterolemia; hypothesis-generating for atherothrombotic mechanisms and requires clinical validation.
Does LDL inhibit the Na+/H+ antiport in human platelets and augment platelet reactivity?
LDL inhibits the Na+/H+ antiport in platelets via receptor-independent mechanisms, augmenting platelet reactivity and potentially contributing to its atherogenic effects.
Nofer et al. (1997) studied this question.
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